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   Technology and Product Development

    Basic Information

Technology developed: Process for the Laser Assisted Synthesis of Nano-hydroxyapatite and Thereof (TP19761558951)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Ashok Kumar IIT Kanpur BSBE Professor
Shazia Shaikh IIT Kanpur BSBE Project Scientist
Ankita Mishra IIT Kanpur BSBE Post Doc
Technical Application Area: Chemicals & Materials Science
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Ministry of Education
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Lab-scale
Please describe in detail including the TRL Level:
The plan is being executed

    Abstract:

Applications: Bone defects occur due to various reasons, like trauma, surgery, tumour, accidents, sports related injuries, bone related diseases etc. These defects require bone tissue replacement or regeneration for enhanced recovery. Bone defects can be of critical size at low and high load bearing regions. For defects in low load bearing regions, bone substitutes are generally used as bone healing implants. These bone substitutes comprise of biocompatible materials, with properties similar to natural bone components like nano hydroxyapatite (nHAP). Majorly, human bone (around 70 percent) consists of nHAP. nHAP is a calcium phosphate-based bio-ceramic with excellent biocompatibility and osteoconductivity. At nano-size this bone apatite allows enhanced biological interactions, thereby emphasizing the importance of nanosized HAP (nHAP) synthesis for generation of high-quality biomedical bone implants for clinical and non-clinical industrial applications. Previous studies have reported numerous protocols for the synthesis of nano-sized nHAP molecules. However, the existing protocols require modifications, for developing a methodology which is less time consuming, reproducible and would yield products with close similarity to natural bone nHAP. In the present invention we have employed a non-contacting nanosecond pulsed laser for the synthesis of nano-HAP. Till date, no reports are available on laser-based synthesis of nHAP, and this study is the first to report utilisation of pulsed laser for the synthesis of nanosized nHAP. This invention is unique as compared to other conventional methods employed for nano-HAP synthesis, since the time of synthesis is significantly reduced due to the involvement of laser. With this technological advancement, we have obtained uniform rod-shaped high purity nHAP pellets with adequate biocompatibility, osteoconductivity and biodegradability.
Advantages: Bone defects arising due to trauma, surgery, infection, tumour, bone related diseases etc. may be restored or regenerated with bone fillers. Usually, bone fillers are bio-ceramics made up of biocompatible molecules, like nHAP, displaying close resemblance to natural human bone. Several types of calcium phosphate-based bone fillers are available in the implant market. However, the conventional protocols employed for manufacturing such bone implants or substitutes are time consuming, and exhibit relatively less yield. Therefore, there exists a need to develop a process which is less time consuming and display high yield with minimum batch to batch variation. For the same, in the present invention we have described a process for the laser-based synthesis of nHAP. This study is first report on, use of localized energy via laser on the mother solution, comprising of calcium and phosphate source, resulting in nHAP nucleation. The localized energy supplied via laser may be tuned in order to generate matured nHAP nanoparticles of desired size and morphology. nHAP pellets developed in the present invention may be used for biomedical applications as bone substitute, and also for non-medical applications, as catalysts, in water filters, gas sensors, in chromatography, host material for lasers etc.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2020-21
Publications:
Submitted (No.) Published (No.) Year
0 1 2020-21

    Commercialization Potential:

Who are the Potential Licensees? NovaBone Products LLC (USA), Stryker Corporation (USA), AlloSource (USA), Baxter International, Inc. (USA)
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: J.G. Rao Date of Submission: 5-5-2022



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