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   Technology and Product Development

    Basic Information

Technology developed: An in-vivo, intraoperative probe for brain tumour margin delineation and methods thereof. (TP19762797614)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Hardik J Pandya Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Assistant Professo
Arjun B S Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Anil Vishnu G K Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Gokul A M Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Arun Baby Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Shilpa Rao National Institute of Mental Health and Neurosciences, Bengaluru Department of Neuropathology Assistant Professor
Manish Beniwal National Institute of Mental Health and Neurosciences, Bengaluru Department of Neuropathology Professor
Vikas V National Institute of Mental Health and Neurosciences, Bengaluru Department of Neuropathology Associate Professor
Anita Mahadevan National Institute of Mental Health and Neurosciences, Bengaluru Department of Neuropathology Professor
Technical Application Area: Other
If 'Other', please specify:
Intraoperative Brain Tumour Delineation
Please give more details of new technical application area:
Intraoperative Brain Tumour Delineation: Gliomas are the most common type of primary brain tumours Despite some improvements in survival rates the patient prognosis is still relatively poor The median survival rates are in the range of 9 12 months and 2 year survival rates are in the range of 8percent 12percent Surgically removing the tumour resection followed by radiation and chemotherapy is the usual treatment protocol for higher grade Gliomas The accuracy and efficacy of resection strongly influence the effectiveness of chemotherapy and radiation, whilst minimizing damage to surrounding tissues and associated neurological loss Tools that can improve resection quality are thus important for the effective treatment of Gliomas
Organization(s):
Indian Institute of Science (IISc) Bengaluru
National Institute of Mental Health and Neurosciences, Bengaluru
2020-21
2020-21
2020-21
Affiliated Ministry: Select One...
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
No
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
4

    Abstract:

Applications: The product is an intraoperative invivo probe that can delineate tumour margin during brain tumour resection based on variations in electrical or mechanical or optical or pH or thermal or dielectric properties of brain tissues. The probe can increase the extent of resection and the probability of attaining gross tumour resection, thus leading to improved survival rates as well as quality of life among the patients after surgical intervention. It can be also used to understand the electrical or mechanical or optical or pH or thermal or dielectric properties of brain which can be useful for improving the probe as well improving the understanding of the brain. The device can also be used for the resection of other forms of cancer such as breast cancer. It also can address issues such as brain plasticity thereby enhancing the accuracy of brain tumour resection. With realtime results, the probe can aid in quicker intraoperative decision making independently or in conjunction with existing preoperative imaging techniques.
Advantages: Fluorescenceguided surgery, intraoperative MRI, functional MRI, and Raman spectroscopy are few of the well sought out intraoperative techniques for brain tumour delineation. But various studies have highlighted their limitations such as low resolution, difficulties in visualising lowgrade tumours, low sensitivity, long measurement times, high cost of infrastructure, etc. The product can overcome these limitations due to nature of sensing modalities and techniques used to fabricate the product. The product it is one of its kind, with no existing products uses the similar sensing modalities to identify the brain tumour margin intraoperatively. The probe is integrated with biochips or sensors that are multifunctional and measures multiple parameters based on different principles for attaining the best accurate results. Also, using multiple sensing modalities simultaneously, the probe can provide accurate results compared to existing tools and systems. The product can ensure increased extent of resection of tumour thereby improving patient recovery with reduced neurological deficits, reduces recurrence and thereby reducing financial burden and morbidity associated with the treatment. The intraoperative probe comes with its own associated electronics and interface units that are unique by means of the sensing modality they use. This means that the product is standalone and do not require external hardware or software accessories for its functionality. The probe design is such that it can reach out to complex surfaces and can be operated both manually by hand as well as robotically. A virtual representation of tumour margin can be obtained using the data obtained from the probe and will be displayed on the interface unit realtime for assisting the surgeon in resection.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Samsung Tablet 2019-20 85171290
Force sensor 2020-21 90318000
Impedance Analyser 2020-21 903000
Micromanipulator 2017-18 8418990
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Silicon Wafer 2019-20 38180090
Photoresists 2019-20 37071000
Nitinol wires 2020-21 90212900
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
FILAMENT PLA 2019-20 39169090
PCB fabricated 2019-20 85177010
Platinum for deposition 2019-20 71101900
Gold for deposition 2019-20 71081200
Existing R&D Facilities used:
Facilities Year ITC-HS Code
3D printer 2019-20 84775900
Wet Dry Etching 2020-21 84799090
Wirebonder 2020-21 85176990
Universal Testing Machine 2020-21 84864000
Mask Alighner 2020-21 84862000
Thermal and E Beam Evaporators 2020-21 84198980

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2020-21
Publications:
Submitted (No.) Published (No.) Year
0 0 2020-21

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Seimens MAGNETOM Sola MAGNETOM Sola is pre-operative imaging and cannot compensate for brain plasticity
bkMedical bk5000 Pre operative imaging and cannot compensate for brain plasticity
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 25-11-2020



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