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   Technology and Product Development

    Basic Information

Technology developed: A quick, non-invasive and objective method to evaluate Neonatal Auditory pathways and index Auditory (TP19764353323)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Hardik J. Pandya Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Assistant Professor
Rathin K. Joshi Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Ph.D. Scholar
Niranjan H S Indira Gandhi Institute of Child Health Department of Neonatology Associate Professor
Prathik B H Indira Gandhi Institute of Child Health Department of Neonatology Associate Professorx1
Rabeeh P C Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Manuj R Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Saeed Rila B C Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Bhushan V Indian Institute of Science Bengaluru Department of Electronic Systems Engineering (DESE Project Assistant
Manjunath Dandi Karnataka Institute of Medical Sciences Hubli Department of Otorhinolaryngology and Head and Nec Assistant Professor
Mahesh Jayachandra Indian Institute of Science Bengaluru Center for Biosystems science and Engineering Bio design Innovator
Latika Mohan All India Institute of Medical Science Rishikesh Department of Physiology Professor and Head
Technical Application Area: Healthcare
If 'Other', please specify:
Neonatal Screening Tools
Please give more details of new technical application area:
Hearing Deficit is the most prevalent chronic sensory deficit at birth The prevalence of congenital bilateral permanent hearing loss is approximately 1 to 5 per 1000 live births in well baby nurseries and 2 to 4 per 100 infants in babies which are admitted to Neonatal Intensive Care Units More than 80 percent of hearing losses in children are congenital or acquired during the neonatal period Evidence from animal and human studies indicate central auditory pathways do not develop normally in the absence of sound stimulation Therefore early identification and subsequent intervention play a vital role to save a child from permanent disability Auditory Brainstem Response ABR and Otoacoustic Emissions OAE are the current approaches to detect deafness in neonates Both methodologies test a specific early part of the auditory pathway but not its entirety until the perception of sound in the brain Moreover the paucity of the clinicians or audiometric professionals expensive equipment lack of specialized hospitals with audiometry tools and patient follow up are the challenges for the success of current Neonatal Hearing screening programs especially in a resource constrained country like India Non invasive low cost objective screening tools to assess the complete auditory pathway in a quickly are need of the hour
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Karnataka Institute of Medical Sciences, Hubli
Indira Gandhi Institute of Child Health, Bengaluru
All India Institute of Medical Science, Rishikesh
Affiliated Ministry: Select One...
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
4

    Abstract:

Applications: 1. The developed device serves as a Neonatal Hearing Screening tool using Cortical Biopotential (Mismatch Negativity). 2. The developed device aims to design and develop a system to replicate the ABR test and evaluate the performance of the proposed system with the BERA system at affordable cost. 3. The developed device leverage the benefits of Wavelet denoising for optimal test time for Neonatal Hearing Screening. 4. The developed device compare the performance of the Neonatal Hearing Screening tool by analyzing the normative data and auditory deficits from different regions. It also creates an indian normative dataset.
Advantages: 1.ABR and OAE are the existing approaches for Neonatal Hearing Screening, which do not scan the auditory pathway beyond Brainstem region. The product evaluates pathways up to higher cortical regions (after auditory brainstem) should be assessed for NHS. Studies have confirmed that Cortical Auditory Evoked Potentials are comprehensive signature for hearing deficits and maturation of auditory pathway. Lack of complete scan of the auditory pathway is the key gap in current newborn screening methodologies. 2. Most of the regions have implemented two-stage neonatal hearing screening procedure i.e, OAE followed by AABR. However, there exists a lacuna. In newborns suffering from ANSD, cochlear function is normal, and the neonate will not be referred further. This issue can be addressed by the device. 3. As most of the current screening procedure lasts for three to six months, late onset of Sensorineural Hearing Loss (SNHL) can be missed which can result in subsequent deafness. The product can evaluate cortical response (including P1,N1,P2,N2, MMN) that can be used to screen infants and adults for SNH. 4. Neonates with mild to severe hearing loss that cannot be efficiently detected by AABR can also be detected. 5. The product will also overcome the current limitations by checking the complete auditory pathway in a robust, reliable and cost-effective way.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Cyton Biosensing Board 2019-20 8542310000
OpenBCI EEG Headband Kit 2019-20 8544420000
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Arduino Uno and Mega 2019-20 84733030
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
PCB fabricated 2019-20 85177010
FILAMENT PLA 2020-21 39169090
Existing R&D Facilities used:
Facilities Year ITC-HS Code
3D printer 2020-21 84775900

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
MAICO MB 11 BERAphone MAICO MB 11 BERPAphone is screening tool based on Auditory Brainstem Response However it does not o
NATUS ALGO 5 NATUS ALGO 5 is screening tool based on Auditory Brainstem Response However it does not obtain cort
Intelligent Hearing Systems SmartScreener-Plus 2 The system offers you a choice of automated ABR screening OAE screening or both However it does not
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Prof KVS Hari Date of Submission: 25-11-2020



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