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  Digital Catalogue for Technology and Products Development


   Technology and Product Development

    Basic Information

Technology developed: Library of w-transaminases for the manufacture of Active Pharmaceutical Ingredients (API) (TP19764825412)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
B Gopal R Gaikaiwari Indian Institute of Science Molecular Biophysics Unit Professor
R Gaikaiwari Hi-Tech Biosynth Pvt Ltd
Technical Application Area: Biotechnology
If 'Other', please specify:
Green Chemistry
Please give more details of new technical application area:
Use of enzymes and bio synthetic methods for the production of Active Pharmaceutical Ingredients API
Organization(s):
Indian Institute of Science (IISc) Bengaluru
Affiliated Ministry: Select One...
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Futuristic
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
TRL 2

    Abstract:

Applications: NA
Advantages: 1.The method (100) provides seed sequences that are most suitable for structure-based enzyme engineering. 2. The method (100) provides target sequence which is suitable starting point for modification using information from the crystal structure and enzyme assays. 3. The method (100) is widely applicable for the synthesis of other active pharmaceutical ingredients thereby providing a library of w-TA enzymes for industrial applications.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 2147483647 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Codexis, Incorporated, 200 Penobscot Drive, Redwood City, CA 94063, USA. Enzyme Feasibility for commercial production of sitagliptin
Merck Research Laboratories, Merck and Company, Incorporated, Rahway, NJ 07065,
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
No
      Submitted by: Prof KVS Hari Date of Submission: 26-11-2020



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