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   Technology and Product Development

    Basic Information

Technology developed: Exploring the Neurogenic Potential of Bone Marrow Stromal Cells (BMSCs) following the Inhibition of BMP signaling (TP19767757936)
Category: Technology Service/Know how
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Dr. Jonaki Sen Indian Institute of Technology (IIT) Kanpur Biological Sciences & Bioengineering
Dr. Nibedita Lenka Indian Institute of Technology (IIT) Kanpur Biological Sciences & Bioengineering
Dr. Amitabha Bandyopadhyay Indian Institute of Technology (IIT) Kanpur Biological Sciences & Bioengineering
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: Institution Funding (Self Supported)
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Prototype Level
Please describe in detail including the TRL Level:
Ready

    Abstract:

Applications: Bone marrow stromal cells BMSCs are a source of adult stem cells that have the potential of undergoing trans differentiation into multiple cell types including neurons. Thus, they could be utilized for treatment of degenerative diseases of the nervous system where the lost neurons are replaced by new neurons derived from BMSCs. Prior to the initiation of this project we observed that genetic depletion of Bone Morphogenetic Proteins BMP signaling in mouse BMSCs results in their trans differentiation into neuron like cells. This observation served as the motivation to initiate this project through which we propose to extensively characterize these neuron like cells derived from BMSCs after inhibition of BMP signaling. In this context we also propose to examine the interaction of Wnt signaling with BMP siganling in collaboration with Dr. Nibedita Lenka from NCCS, Pune. This study will open up many therapeutic avenues where BMSCs can be used as a readily available source to produce neurons of the desired kind on providing the appropriate molecular environment
Advantages: Bone marrow stromal cells BMSCs are a source of adult stem cells that have the potential of undergoing trans differentiation into multiple cell types including neurons. Thus, they could be utilized for treatment of degenerative diseases of the nervous system where the lost neurons are replaced by new neurons derived from BMSCs. Prior to the initiation of this project we observed that genetic depletion of Bone Morphogenetic Proteins BMP signaling in mouse BMSCs results in their trans differentiation into neuron like cells. This observation served as the motivation to initiate this project through which we propose to extensively characterize these neuron like cells derived from BMSCs after inhibition of BMP signaling. In this context we also propose to examine the interaction of Wnt signaling with BMP siganling in collaboration with Dr. Nibedita Lenka from NCCS, Pune. This study will open up many therapeutic avenues where BMSCs can be used as a readily available source to produce neurons of the desired kind on providing the appropriate molecular environment

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
0 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Technical Team Date of Submission: 1-5-2023



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