Indian Science Technology and Engineering facilities Map
Supplier Map
Service Map










Preivious Next  

  Digital Catalogue for Technology and Products Development


   Technology and Product Development

    Basic Information

Technology developed: Gly-Tag technology (TP19767909252)
Category: Product (Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Vishal Rai Indian Institute of Science Education and Research Bhopal Chemistry Associate Professor
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Labeling of native proteins invites interest from diverse segments of Science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. The Gly-tag technology provides site-specific labeling of natural or easy-to-engineer N-terminus Gly in proteins with remarkable efficiency and selectivity. It differentiates N-Gly as a unique target amongst other proteinogenic amino acids. The method allows single-site labeling of proteins in isolated form and extends to lysed cells. It administers an orthogonal aldehyde group primed for late-stage tagging with an affinity tag, 19F NMR probe, and a fluorophore. A user-friendly protocol delivers analytically pure tagged proteins. The mild reaction conditions do not alter the structure and function of the protein. The cellular uptake of fluorophore-tagged insulin and its ability to activate the insulin-receptor mediated signaling remains unperturbed.
Organization(s):
Indian Institute of Science Education and Research (IISER) Bhopal
Affiliated Ministry: MHRD, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Yes
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Commercialized
Please describe in detail including the TRL Level:
(TRL9) Product and services related to the technology are commercially available through Plabeltech Private Limited.

    Abstract:

Applications: Precision engineering of proteins, Metal-free protein purification, Purification of therapeutic proteins, Precisely engineered Insulin.
Advantages: It is the first ever technological platform that can precisely engineer a single Gly residue at the N-terminus of the protein.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

    R&D Investment:

R&D investment (Rs. in Lakhs):                    
Indian Source (Rs.) Foreign Source (Rs.) Year
6000000 0 2019-20

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
2 0 NA
Publications:
Submitted (No.) Published (No.) Year
0 1 2018-19

    Commercialization Potential:

Who are the Potential Licensees? Plabeltech Private Limited
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Sarita Panwar Date of Submission: 4-8-2020



THE VISION
THE MISSION
ABOUT I-STEM
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
read more >>

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Toll Free Number : 1800 425 3281     IVR Number : 9620203281
Hosted at Indian Institute of Science
Copyright © 2020 I-STEM. All rights reserved    Audited by: STQC Bengaluru.