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  Digital Catalogue for Technology and Products Development

   Technology and Product Development

    Basic Information

Technology developed: Gly-Tag technology (TP19767909252)
Category: Product (Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Vishal Rai Indian Institute of Science Education and Research Bhopal Chemistry Associate Professor
Technical Application Area: Biotechnology
If 'Other', please specify:
Please give more details of new technical application area:
Labeling of native proteins invites interest from diverse segments of Science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. The Gly-tag technology provides site-specific labeling of natural or easy-to-engineer N-terminus Gly in proteins with remarkable efficiency and selectivity. It differentiates N-Gly as a unique target amongst other proteinogenic amino acids. The method allows single-site labeling of proteins in isolated form and extends to lysed cells. It administers an orthogonal aldehyde group primed for late-stage tagging with an affinity tag, 19F NMR probe, and a fluorophore. A user-friendly protocol delivers analytically pure tagged proteins. The mild reaction conditions do not alter the structure and function of the protein. The cellular uptake of fluorophore-tagged insulin and its ability to activate the insulin-receptor mediated signaling remains unperturbed.
Indian Institute of Science Education and Research (IISER) Bhopal
Affiliated Ministry: MHRD, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Does the technology have export potential? Yes
Category of Technology developed: Immediate Deployment
Stage of Development: Commercialized
Please describe in detail including the TRL Level:
(TRL9) Product and services related to the technology are commercially available through Plabeltech Private Limited.


Applications: Precision engineering of proteins, Metal-free protein purification, Purification of therapeutic proteins, Precisely engineered Insulin.
Advantages: It is the first ever technological platform that can precisely engineer a single Gly residue at the N-terminus of the protein.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
Existing R&D Facilities used:
Facilities Year ITC-HS Code

    R&D Investment:

R&D investment (Rs. in Lakhs):                    
Indian Source (Rs.) Foreign Source (Rs.) Year
6000000 0 2019-20

   Patents & Publications:

Filed Patents (No.) Granted Patents (No.) Year
2 0 NA
Submitted (No.) Published (No.) Year
0 1 2018-19

    Commercialization Potential:

Who are the Potential Licensees? Plabeltech Private Limited
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
      Submitted by: Sarita Panwar Date of Submission: 4-8-2020

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