Indian Science Technology and Engineering facilities Map
Supplier Map
Service Map
Preivious Next  

  Digital Catalogue for Technology and Products Development

   Technology and Product Development

    Basic Information

Technology developed: A Highly-stable Therapeutic Protein Antigen having Vaccine Application against Shigellosis (TP19769035843)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Dr. Dhirendra S. Katti IIT Kanpur Biological Sciences & Bioengineering Faculty Member
Dr. Nadim Ahamad IIT Kanpur Biological Sciences & Bioengineering Faculty Member
Ms. Namrata Baruah IIT Kanpur Biological Sciences & Bioengineering Student
Technical Application Area: Healthcare
If 'Other', please specify:
Please give more details of new technical application area:
Indian Institute of Technology (IIT) Kanpur
Affiliated Ministry: MHRD, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Does the technology have export potential? 1
Category of Technology developed: Futuristic
Stage of Development: Lab-scale
Please describe in detail including the TRL Level:
TRL Level 5


Applications: 1. The present invention provides a simple and cost-effective method of increasing stability and storage time of a protein antigen. This method is used to obtain stable Shigella dysenteriae IpaC protein with higher yield that can be stored for longer duration without changing its secondary structure. 2. The present invention discloses an effective vaccine against Shigellosis which was found to be protective in BALBc mice against a more than lethal challenge of Shigella flexneri. The primary objective of the present invention is to provide a simple and cost-effective method of increasing stability and storage time of a protein antigen having potential vaccine applications.
Advantages: 1. Purification of protein for various purposes such as vaccine, diagnostic kits for disease detection/detection of a condition, health industry, food industry, etc. 2. Due to reduced cost and energy it would allow easy manufacturing of therapeutic proteins. 3. Increased durability means more shelf life or storage time. 4. As the protein can be stable at room temperature, storage in cold temperature or transportation in ice or dry ice can be reduced or negated. This can help target developing countries where cold storage may be a hindrance due to disruptive or absence of continuous electricity supply. 5. IpaC can be used along with other therapeutic proteins to form a multivaccine formulation i.e., a single vaccine protecting against multiple diseases.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
Imported Raw Materials:
Raw Materials Year ITC-HS Code
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
Existing R&D Facilities used:
Facilities Year ITC-HS Code

    R&D Investment:

R&D investment (Rs. in Lakhs):                    
Indian Source (Rs.) Foreign Source (Rs.) Year
0 0 NA

   Patents & Publications:

Filed Patents (No.) Granted Patents (No.) Year
1 0 2019-20
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
      Submitted by: Tarun Gupta Date of Submission: 4-8-2020

I-Mitra(आई-मित्र) Welcomes You..
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Hosted at Indian Institute of Science
Copyright © 2020 I-STEM. All rights reserved.
Audited by: STQC Bengaluru.