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Patent Details

Applicant:
Indian Institute of Technology (IIT) Roorkee 
Title:
Surface modified metallic orthopedic implant for sustained drug release 
Inventor(s):
Debrupa Lahiri, Partha Roy and Manoj Kumar Rangaswamy 
Applicant:
Indian Institute of Technology (IIT) Roorkee 
Application type:
Applied - 2017-07-13 
Application Number:
201711024735 
Applied at:
India 
Entered by:
Indian Institute of Technology (IIT) Roorkee 
Abstract:
In an aspect of the invention, there is provided an orthopedic metallic implant for sustained release of drug comprising an interconnected micro porous coating layer of a bioactive ceramic material on the surface of said metallic implant wherein said porous coating comprises pores impregnated with biodegradable polymer containing drug wherein said impregnation of biodegradable polymer containing drug is limited to said pores and the surface of said ceramic layer not covered by said pores remains exposed for enhanced osteo-conductive and mechanical property. In another aspect of the invention, there is provided a method of preparing an orthopedic metallic implant as mentioned above, wherein said method is based on plasma spraying technique and impregnation technique, comprising the steps of: a) Modifying the interconnected micro porous bioactive ceramic coating layer present on said metal implant through plasma spraying technique; b) Loading a drug with compatible biodegradable polymer solution into pores through vacuum impregnation chamber wherein said impregnation of biodegradable polymer containing drug is limited to said pores and surface of said ceramic layer not covered by said pores remains exposed for enhanced osteo-conductive and bone integration properties.  

 
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