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Patent Details

Applicant:
Indian Institute of Technology (IIT) Roorkee 
Title:
Asparaginase and its variants 
Inventor(s):
Naveen Kumar Navani*, and Tamoghna Ghosh 
Applicant:
Indian Institute of Technology (IIT) Roorkee 
Application type:
Applied - 2018-05-03 
Application Number:
201811019299 
Applied at:
India 
Entered by:
Indian Institute of Technology (IIT) Roorkee 
Abstract:
The present invention is to provide an effective mutant of bacterial enzyme from probiotic source i.e. Lactobacillus brevis NKN55 with improved efficacy and thermostability useful for therapeutics and food industry. L-asparaginase increased enzymatic reaction optimum temperatures with no significant alteration to substrate affinity and reaction velocity. The substrate affinity of the mutant enzyme was calculated by Michaelis-Menten equation. It also provide therapeutically effective and immunologically-distinct, alternative and stable mutated form of L-asparaginase enzyme from a food grade probiotic lactic acid bacterium and also by using site specific mutagenesis. 

 
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It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
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However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

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