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Applicant:
Indian Institute of Technology (IIT) Gandhinagar 
Title:
SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[4,3-C]QUINOLIN-3-ONE AS ATR KINASE INHIBITORS 
Inventor(s):
Prof Sivapriya Kirubakaran, Prof Vijay Thiruvenkatam, Mr Shaik Althaf, Ms Bhakuni Rashmi 
Applicant:
Indian Institute of Technology (IIT) Gandhinagar 
Application type:
Applied - 2016-08-02 
Application Number:
201621026397 
Applied at:
India 
Entered by:
Indian Institute of Technology (IIT) Gandhinagar 
Abstract:
The present disclosure relates to substituted 1,2-dihydro-3h-pyrazolo[4,3- c]quinolin-3-one of Formula-Q as ATR kinase inhibitors. Formula-Q wherein, R is selected from the group consisting of hydrogen and alkyl group; 30 wherein, R1, R2, and R3 are independently selected from the group consisting of hydrogen or alkyl, Z is nitrogen at different positions, X is selected from the group consisting of halogen, alkyl, haloalkyl, or cyano, and Y is selected from the group consisting of nitrogen, and oxygen. A process for preparation of compounds of Formula-Q is also disclosed. The pharmaceutical composition of compound of Formula-Q can be used as an ATR kinase inhibitor. 

 
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