Indian Science Technology and Engineering facilities Map
 
Supplier Map
Service Map

Patents

Patent Details

Applicant:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Title:
A Nanosphere-Histone Acethyltransferase (HAT) Activator Composition and Process Thereof  
Inventor(s):
Tapas Kumar Kundu, Anne-Laurence Boutillier, Snehajyoti Chatterjee, Muthusamy Eswarmoorthy, Puspak Mizar, Chantal Mathis, Jean-Christophe Cassel, Romain Neidl, Mohankrishna Dalvoy Vasudevarao, Vedamurthy Bhusainahalli Maheswarappa 
Application type:
Granted - 2019-04-10 
Application Number:
311070 
Applied at:
India 
Entered by:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Abstract:
The present disclosure is in relation to a composition comprising nanosphere and histone acetyltransferase (HAT) activator. The disclosed nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-rifluoromethylphenyl)- 2-npropoxy-benzamide [COMPOUND 1]. The said N-(4-Chloro-3-trifluoromethylphenyl)- 2-npropoxy-benzamide is covalently conjugated with the carbon nanosphere. The present disclosure further relates to a process for obtaining a composition comprising carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethylphenyl)- 2-n-propoxybenzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The said composition thus provides for managing pathological conditions to a subject in need thereof, such as agingrelated, neurodegenerative diseases (Alzheimer’s in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit. 

 
THE VISION
THE MISSION
ABOUT I-STEM
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
read more >>

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Hosted at Indian Institute of Science
Copyright © 2024 I-STEM. All rights reserved.
Audited by: STQC Bengaluru.