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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
A Nanosphere-Histone Acethyltransferase (HAT) Activator Composition and Process Thereof  
Tapas Kumar Kundu, Anne-Laurence Boutillier, Snehajyoti Chatterjee, Muthusamy Eswarmoorthy, Puspak Mizar, Chantal Mathis, Jean-Christophe Cassel, Romain Neidl, Mohankrishna Dalvoy Vasudevarao, Vedamurthy Bhusainahalli Maheswarappa 
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Application type:
Granted - 2019-04-10 
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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
The present disclosure is in relation to a composition comprising nanosphere and histone acetyltransferase (HAT) activator. The disclosed nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-rifluoromethylphenyl)- 2-npropoxy-benzamide [COMPOUND 1]. The said N-(4-Chloro-3-trifluoromethylphenyl)- 2-npropoxy-benzamide is covalently conjugated with the carbon nanosphere. The present disclosure further relates to a process for obtaining a composition comprising carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethylphenyl)- 2-n-propoxybenzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The said composition thus provides for managing pathological conditions to a subject in need thereof, such as agingrelated, neurodegenerative diseases (Alzheimer’s in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit. 

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