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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
A Composite, Scaffold and Applications Thereof  
Govindaraju Thimmaiah, Shivaprasad Manchineella 
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Application type:
Applied - 2016-02-10 
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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Biomaterial scaffolds with desired physical properties such as stiffness, topography, magnetic and conducting properties along with cell adhesion and proliferation cues finds potential use for tissue engineering and regenerative medicine applications. Scaffolds that are biocompatible, biodegradable and bioresorbabale along with other desirable physical and chemical properties are most sought after for both in vitro and in vivo applications. The soft biomaterial scaffolds, which are made from synthetic polymers, suffer the limitations such as the toxicity associated with their synthesis or degradation, batch-to-batch integrity of polymers and the requirement of additional biofunctionalisation to facilitate cell adhesion and proliferation. Biomaterial scaffolds that are made from materials of biological origin will address the limitation associated with synthetic polymer based scaffolds. However, the industrial scale availability, stability and ease of processability and moldability into different scaffold formats limit the use of many biopolymers largely. We have chosen silk fibroin protein, extracted from domestic silk worm Bombyx mori cocoons as the source of biopolymer to prepare smart biomaterial scaffolds owing to its large scale availability, non-toxicity both in vitro and in vivo and ability to mold into different scaffold material formats for various tissue engineering and regenerative medicine applications.  

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