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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Carbon Nanosphere-Folate Receptor Targeting Ligand Conjugate, Complex and Composition and Method of Preparation Thereof  
Tapas Kumar Kundu, Muthusamy Eswaramoorthy, Rajkumar Banerjee, Chandra Kumar Elechelawar, Sarmistha Halder Sinha 
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
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Applied - 2018-03-13 
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Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Glioblastomamultiforme is the most invasive form of glioma. The patients’ssurvibility rate in glioma tumor is very low. Folate receptors are overexpressing in many cancer including glioma and TAM. So here we have targeted both folate receptor and Tumor associated Macrophages (TAM) using blood brain barrier (BBB) permeable carbon nanosphere (CSP). Carbon nanosphere has been used as delivery vehicle by conjugating with acid cationic lipid conjugate (F8) receptor. In the recent manuscript doxorubicin has been conjugated with CF8 material and that material was treated in Glioma tumor bearing mice. Tumor size and TAM associated pro-aggressive marker TGFβ and STAT3also have been deceased and mice survibility has increased indicating doxorubicin is reaching to the glioma tumor sites by CF8 delivery vehicle and reducing the tumor growth. So CF8 is the potential delivery vehicle for the treatment of glioma tumor. So first time we are reporting CF8 material as patentable delivery vehicle. 

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