Indian Science Technology and Engineering facilities Map
 
Supplier Map
Service Map

Patents

Patent Details

Applicant:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Title:
Carbon Nanosphere-Folate Receptor Targeting Ligand Conjugate, Complex and Composition and Method of Preparation Thereof  
Inventor(s):
Tapas Kumar Kundu, Muthusamy Eswaramoorthy, Rajkumar Banerjee, Chandra Kumar Elechelawar, Sarmistha Halder Sinha 
Application type:
Applied - 2018-03-13 
Application Number:
201841009113 
Applied at:
India 
Entered by:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Abstract:
Glioblastomamultiforme is the most invasive form of glioma. The patients’ssurvibility rate in glioma tumor is very low. Folate receptors are overexpressing in many cancer including glioma and TAM. So here we have targeted both folate receptor and Tumor associated Macrophages (TAM) using blood brain barrier (BBB) permeable carbon nanosphere (CSP). Carbon nanosphere has been used as delivery vehicle by conjugating with acid cationic lipid conjugate (F8) receptor. In the recent manuscript doxorubicin has been conjugated with CF8 material and that material was treated in Glioma tumor bearing mice. Tumor size and TAM associated pro-aggressive marker TGFβ and STAT3also have been deceased and mice survibility has increased indicating doxorubicin is reaching to the glioma tumor sites by CF8 delivery vehicle and reducing the tumor growth. So CF8 is the potential delivery vehicle for the treatment of glioma tumor. So first time we are reporting CF8 material as patentable delivery vehicle. 

 
THE VISION
THE MISSION
ABOUT I-STEM
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
read more >>

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Hosted at Indian Institute of Science
Copyright © 2024 I-STEM. All rights reserved.
Audited by: STQC Bengaluru.