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Applicant:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Title:
Recombinant Vector Comprising HIV-LTR Promoter, And Associated High Throughput Screening Method  
Inventor(s):
Ranga Udaykumar 
Applicant:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Application type:
Applied - 2019-02-14 
Application Number:
201941005934 
Applied at:
India 
Entered by:
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bengaluru 
Abstract:
The present disclosure discloses a recombinant 5 vector comprising an HIV-LTR (Human Immuno-deficiency virus-Long Terminal Repeat) promoter comprising a nucleic acid sequence as set forth in SEQ ID NO : 1 or SEQ ID NO:5 or SEQ ID NO:6, at least one heterologous reporter gene, and at least one HIV-specific gene, wherein said HIV-specific gene encodes an HIV-specific protein under the control 10 of the HIV-LTR promoter, and wherein the HIV-specific protein modulates activity of the HIV-LTR promoter. Further, the present disclosure also discloses a method for screnning candidate molecule capable of modulating transcription of Tat gene from HIV-LTR promoter comprising a nucleic acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 5 or SEQ ID NO: 6. A method for obtaining stable cell 15 population comprising two recombinant vectors is also described herein. 

 
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