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Applicant:
Central University of Tamil Nadu 
Title:
Licochalcone-A and/or Its Derivatives For Inducing Neuronal Differentiation 
Inventor(s):
Siva Sundara Kumar Durairajan, Nagarajan Samuthiram N, Shiva Prasad M 
Applicant:
Central University of Tamil Nadu 
Application type:
Provisional - 2019-09-24 
Application Number:
201941038499 
Applied at:
India 
Entered by:
Central University of Tamil Nadu 
Abstract:
Licochalcone A (1) is a major polyphenolic compound from Glycyrrhiza inflata (licorice). Licochalcone A exerts multiple biological activities such as anti-oxidative, neuroprotective, antibacterial, anti-stroke, osteogenic, anti-inflammatory activity and antidepressant activity. These findings indicate that Licochalcone A are ideal candidates for treating neurological and neurodegenerative diseases. Although the crystal structure of LA has been revealed, there apparently have been few attempts to modify its structure for improving its neuritogenic and anti-neurodegenerative activity. As best of our knowledge, we report for the first time that Licochalcone A and its derivatives (2) or (3) or their combination induced the differentiation of mammalian P19 embryonic stems cells to neuronal cell lines in vitro. By screening a series of Licochalcone A synthetic analogues 2 or 3 or 4, we identified only 1, 2 and 3 but not 4 induced neuronal differentiation of pluripotent P19 cells at 5 μM concentration of each compound from 1 to 7th day. In addition, Licochalcone A (1) and its derivatives (2 and 3) treated cells showed increased level of TuJ1 (a neuronal βIII tubulin differentiating specific marker) and the greater level of TuJ1 was observed in order of 3>2>1. The present study thus provides an effective method for the re-programming of mouse embryonic stem cells toward neuronal cells, using Licochalcone-A and/or its derivatives. 

 
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