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Indian Institute of Technology (IIT) Patna 
Shikha Rani, Ajay Kumar Singh, Ravi Ranjan Paswan, Dinesh Kumar Kotnees, Rakesh Kumar 
Corresponding Authors:
Dinesh Kumar Kotnees, Rakesh Kumar 
DOI #: 
Preparation, Characterization and Antibacterial Evaluation of Soy Protein Isolate Biopolymeric Films Loaded with Nalidixic Acid, 
Journal of Polymers and the Environment 
Soy protein isolate · Nalidixic acid · Biopolymeric flm · Tensile stress · Molecular docking · Antibacterial properties 
Glycerol plasticized soy protein isolate (SPI) flms at diferent contents (1 to 5% w/w w.r.t SPI) of nalidixic acid (NA) were fabricated by solution casting method. SPI flms and NA incorporated SPI flms were structurally and mechanically characterized by Fourier transform infrared spectroscopy (FTIR) and mechanical properties, respectively. Thermomechanical and water uptake studies were also carried out for NA incorporated SPI flms. The results from FTIR study indicated the presence of NA in SPI as evidenced by generation of two additional peaks at 1259 cm−1 and 800 cm−1 attributed to C–C stretching vibration and the deformation of the heterocyclic aromatic ring, respectively. At 4% NA, the tensile stress and tensile modulus of SPI flms increased from 5.18 MPa to 8.57 MPa and 57.14 MPa to 93.90 MPa, respectively. Antibacterial activity of NA incorporated SPI flms against E. coli and L. monocytogenes were studied. The antibacterial studies of NA incorporated SPI flm showed the clear zone of inhibition against both the bacteria. Docking studies were performed for SPI in order to evaluate their binding afnity with NA and similar type of aromatic acids such as mandelic and benzilic acid with which SPI flms have been prepared earlier by our group. After docking, the ligands in form of aromatic acids were evaluated according to their binding energy and the interaction pattern between SPI and aromatic acids. The docking results indicated that nitrogen containing heterocyclic ring moiety remained intact during interaction of SPI and NA. This work will be helpful in fabricating NA incorporated SPI flm from the renewable resources with signifcant antibacterial properties and reasonable mechanical properties.  
Entered by:
Venkata Dantham on 2020-08-04 
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