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Applicant:
Central University of Tamil Nadu 
Author:
A. Karthika, L. Kavitha, M. Surendiran, S. Kannan and D. Gopi 
Corresponding Authors:
D. Gopi 
DOI #:
doi.org/10.1039/C5RA05624A 
Title:
Fabrication of divalent ion substituted hydroxyapatite/gelatin nanocomposite coating on electron beam treated titanium: mechanical, anticorrosive, antibacterial and bioactive evaluations 
Journal:
RSC Advances 
Year:
2015 
Volume:
Page:
47341-47352 
Keywords:
Titanium; Hydroxyapatite; Gelatin; Nanocomposite; orthopedic applications 
Abstract:
The key property in the fabrication of a biomaterial is to facilitate the replacement and/or regeneration of damaged tissues and organs. To obtain such a biomaterial, we fabricated a triple mineral (strontium, magnesium and zinc) substituted hydroxyapatite/gelatin (M-HAP/Gel) nanocomposite coating on electron beam treated titanium (Ti) metal. The influence of gelatin concentration in M-HAP was studied to investigate its effect on morphological changes, crystallinity, mechanical and anticorrosion properties. The M-HAP/Gel nanocomposite coating (with 3 wt% gelatin) on treated Ti resulted in better mechanical and anticorrosion properties as a consequence of the electron beam treatment of Ti. A reduced number of bacterial colonies were observed for the M-HAP/Gel composite against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) microbes which evidences a lower chance of implant failure after implantation. Moreover, the cell proliferation assay, live/dead staining of MT3C3-E1 cells and cell viability of fibroblast stem cells on the resultant nanocomposite revealed that the M-HAP/Gel composite will definitely be an effective implant material for better cell growth in orthopedic applications. 
Entered by:
Kavitha Louis on 2020-09-03 
 
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