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Applicant:
Central University of Tamil Nadu 
Author:
S. Ramya, E. Shinyjoy, L. Kavitha, S. Kannan and D. Gopi 
Corresponding Authors:
D. Gopi 
DOI #:
doi.org/10.1021/acsami.6b01795 
Title:
Fabrication of minerals substituted porous hydroxyapaptite/poly (3,4-ethylenedioxy pyrrole-co-3,4- ethylenedioxythiophene) bilayer coatings on surgical grade stainless steel and its antibacterial and biological activities for orthopedic applications 
Journal:
Applied Materials & Interfaces 
Year:
2016 
Volume:
Page:
12404–12421 
Keywords:
poly(3,4-ethylenedioxypyrrole), poly(3,4-ethylenedioxythiophene), substituted hydroxyapatite, bilayer, electrodeposition, bioactivity 
Abstract:
Current strategies of bilayer technology have been aimed mainly at the enhancement of bioactivity, mechanical property and corrosion resistance. In the present investigation, the electropolymerization of poly(3,4-ethylenedioxypyrrole-co-3,4-ethylenedioxythiophene) (P(EDOP-co-EDOT)) with various feed ratios of EDOP/EDOT on surgical grade stainless steel (316L SS) and the successive electrodeposition of strontium (Sr2+), magnesium (Mg2+) and cerium (Ce3+) (with 0.05, 0.075 and 0.1 M Ce3+) substituted porous hydroxyapatite (M-HA) are successfully combined to produce the bioactive and corrosion resistance P(EDOP-co-EDOT)/M-HA bilayer coatings for orthopedic applications. The existence of as-developed coatings was confirmed by Fourier transform-infrared spectroscopy (FT-IR), X-ray diffraction (XRD), proton nuclear magnetic resonance spectroscopy (1H NMR), high resolution scanning electron microscopy (HRSEM), energy dispersive X-ray analysis (EDAX) and atomic force microscopy (AFM). Also, the mechanical and thermal behavior of the bilayer coatings were analyzed. The corrosion resistance of the as-developed coatings and also the influence of copolymer (EDOP:EDOT) feed ratio were studied in Ringer’s solution by electrochemical techniques. The as-obtained results are in accord with those obtained from the chemical analysis using inductively coupled plasma atomic emission spectrometry (ICP-AES). In addition, the antibacterial activity, in vitro bioactivity, cell viability and cell adhesion tests were performed to substantiate the biocompatibility of P(EDOP-co-EDOT)/M-HA bilayer coatings. On account of these investigations, it is proved that the as-developed bilayer coatings exhibit superior bioactivity and improved corrosion resistance over 316L SS, which is potential for orthopedic applications. 
Entered by:
Kavitha Louis on 2020-09-03 
 
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