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Applicant:
Central University of Tamil Nadu 
Author:
N.Ayyappan, Pavithra T, Christy Maria Joy, L. Kavitha 
Corresponding Authors:
L. Kavitha 
DOI #:
ISSN 2320- 4338 
Title:
Effect of Twist and Nonlinear Dynamics of Anharmonic Twist Opening Model of DNA 
Journal:
Engineering Sciences International Research Journal 
Year:
2019 
Volume:
Page:
47-50 
Keywords:
DNA Twisting, Fourier Approximation, Modulational Instability Analysis 
Abstract:
In this paper, we investigate the play role of twisting in the dynamics of DNA by considering anharmonic twist opening model. In this model, we consider the coupling between opening of base pairs and twist of the strand responsible for helicoidal structure of B-DNA. We derive the dynamical equations and recast them as two Coupled Discrete Nonlinear Schrodinger equations (CDNLS) by employing Fourier approximation method. Further, we perform the linear stability analysis and it is observed that the soliton profile is generated when the instability occurs. It is shown that the instability increases with the increase of the degree of twisting and this may cause genetic disorder related diseases in DNA system. The analytical predictions are confirmed with the numerical dynamics of molecular dynamical simulations performed and verified the same 
Entered by:
Kavitha Louis on 2020-09-03 
 
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