| | | | | | | |
                
Indian Science Technology and Engineering facilities Map
Supplier Map
Service Map










Publications

Publication Details

Applicant:
Central University of Tamil Nadu 
Author:
Baba AB, Nivetha R, Chattopadhyay I, Nagini S. 
Corresponding Authors:
Nagini S. 
DOI #:
doi:10.1016/j.fct.2017.09.054 
Title:
Blueberry and malvidin inhibit cell cycle progression and induce mitochondrial-mediated apoptosis by abrogating the JAK/STAT-3 signalling pathway. 
Journal:
Food Chem Toxicol. 
Year:
2017 
Volume:
109 
Page:
534-543 
Keywords:
Apoptosis; Blueberry; Cell cycle; Hamster buccal pouch carcinogenesis; Malvidin; STAT-3. 
Abstract:
Blueberries, a rich source of anthocyanins have attracted considerable attention as functional foods that confer immense health benefits including anticancer properties. Herein, we assessed the potential of blueberry and its major constituent malvidin to target STAT-3, a potentially druggable oncogenic transcription factor with high therapeutic index. We demonstrate that blueberry abrogates the JAK/STAT-3 pathway and modulates downstream targets that influence cell proliferation and apoptosis in a hamster model of oral oncogenesis. Further, we provide mechanistic evidence that blueberry and malvidin function as STAT-3 inhibitors in the oral cancer cell line SCC131. Blueberry and malvidin suppressed STAT-3 phosphorylation and nuclear translocation thereby inducing cell cycle arrest and mitochondrial-mediated apoptosis. However, the combination of blueberry and malvidin with the STAT-3 inhibitor S3I-201 was more efficacious in STAT-3 inhibition relative to single agents. The present study has provided leads for the development of novel combinations of compounds that can serve as inhibitors of STAT-mediated oncogenic signalling. 
Entered by:
Indranil Chattopadhyay on 2020-09-03 
 
THE VISION
THE MISSION
ABOUT I-STEM
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
read more >>

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Toll Free Number : 1800 425 3281
Hosted at Indian Institute of Science
Copyright © 2019 I-STEM. All rights reserved    Audited by: STQC Bengaluru.