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Central University of Tamil Nadu 
Devojit Kumar Sarma, Pradumnya Kishore Mohapatra, Dibya Ranjan Bhattacharyya, Savitha Chellappan, Balasubramani Karuppusamy, Keshab Barman, Nachimuthu Senthil Kumar, Aditya Prasad Dash, Anil Prakash, Praveen Balabaskaran Nina 
Corresponding Authors:
Praveen Balabaskaran Nina, Anil Prakash 
DOI #:
Malaria in North-East India: Importance and Implications in the Era of Elimination 
Dec 10;7(12):673 
Not applicable 
An. baimaii; An. minimus; North-East India; P. falciparum; P. vivax; artemisinin combination therapy. 
Worldwide and in India, malaria elimination efforts are being ramped up to eradicate the disease by 2030. Malaria elimination efforts in North-East (NE) India will have a great bearing on the overall efforts to eradicate malaria in the rest of India. The first cases of chloroquine and sulfadoxine-pyrimethamine resistance were reported in NE India, and the source of these drug resistant parasites are most likely from South East Asia (SEA). NE India is the only land route through which the parasites from SEA can enter the Indian mainland. India's malaria drug policy had to be constantly updated due to the emergence of drug resistant parasites in NE India. Malaria is highly endemic in many parts of NE India, and Plasmodium falciparum is responsible for the majority of the cases. Highly efficient primary vectors and emerging secondary vectors complicate malaria elimination efforts in NE India. Many of the high transmission zones in NE India are tribal belts, and are difficult to access. The review details the malaria epidemiology in seven NE Indian states from 2008 to 2018. In addition, the origin and evolution of resistance to major anti-malarials are discussed. Furthermore, the bionomics of primary vectors and emergence of secondary malaria vectors, and possible strategies to prevent and control malaria in NE are outlined. 
Entered by:
Praveen Balabaskaran Nina on 2020-09-03 
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