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Applicant:
Central University of Tamil Nadu 
Author:
Indranil Chattopadhyay 
Corresponding Authors:
Indranil Chattopadhyay 
DOI #:
DOI: 10.4103/jrcr.jrcr_8_17 
Title:
Application of radiogenomics in radiation oncology 
Journal:
Journal of Radiation and Cancer Research 
Year:
2017 
Volume:
Page:
74-76 
Keywords:
Radiation, genomics, cancer, therapy 
Abstract:
Radiotherapy (RT) can be used in the treatment of cancers, instead of surgery to achieve better functional results by using external beam RT and brachytherapy. Elevation of radiation response in tumor cells and reduction of sensitivity to radiation in adjacent normal tissues are the core issues in the radiotherapeutic field of tumor. Radiogenomics addresses possible associations between germline genetic variation and normal tissue toxicity after RT. The objective of radiation genomics is to identify the genetic markers for personalized RT, in which cancer management is formulated so that the treatment plan will be optimized for each patient based on their genetic background. Combinatorial approaches to radiation-induced gene expression study and genome-wide SNP genotype study may discover candidate biomarkers for personalization of RT treatment and identify genetic alterations that affect risk of normal tissue toxicity. 
Entered by:
Indranil Chattopadhyay on 2020-09-03 
 
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