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Applicant:
Central University of Tamil Nadu 
Author:
Ajeet Kumar Mohanty, Praveen Balabaskaran Nina, Shuvankar Ballav, Smita Vernekar, Sushma Parkar , Maria D'souza, Wenyun Zuo, Edwin Gomes, Laura Chery, Shripad Tuljapurkar, Neena Valecha, Pradipsinh K Rathod, Ashwani Kumar 
Corresponding Authors:
Ashwani Kumar 
DOI #:
10.1186/s12936-018-2343-0 
Title:
Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection 
Journal:
Malaria Journal 
Year:
2018 
Volume:
Jun 5;17(1):225 
Page:
Not applicable 
Keywords:
P. falciparum, An. stephensi 
Abstract:
Background: As much as 80% of global Plasmodium vivax infections occur in South Asia and there is a shortage of direct studies on infectivity of P. vivax in Anopheles stephensi, the most common urban mosquito carrying human malaria. In this quest, the possible effects of laboratory colonization of mosquitoes on infectivity and development of P. vivax is of interest given that colonized mosquitoes can be genetically less divergent than the field population from which they originated. Methods: Patient-derived P. vivax infected blood was fed to age-matched wild and colonized An. stephensi. Such a comparison requires coordinated availability of same-age wild and colonized mosquito populations. Here, P. vivax infection are studied in colonized An. stephensi in their 66th-86th generation and fresh field-caught An. stephensi. Wild mosquitoes were caught as larvae and pupae and allowed to develop into adult mosquitoes in the insectary. Parasite development to oocyst and sporozoite stages were assessed on days 7/8 and 12/13, respectively. Results: While there were batch to batch variations in infectivity of individual patient-derived P. vivax samples, both wild and colonized An. stephensi were roughly equally susceptible to oocyst stage Plasmodium infection. At the level of sporozoite development, significantly more mosquitoes with sporozoite load of 4+ were seen in wild than in colonized populations. 
Entered by:
Praveen Balabaskaran Nina on 2020-09-03 
 
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