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Applicant:
Central University of Tamil Nadu 
Author:
Savitha Chellappan, Subarna Roy, Jyoti M Nagmoti, Wahida Tabassum, SL Hoti, Mrinal Kanti Bhattacharyya, Praveen Balabaskaran Nina 
Corresponding Authors:
Praveen Balabaskaran Nina 
DOI #:
10.4103/ijmm.IJMM_20_28 
Title:
Functional studies of Plasmodium falciparum's prohibitin1 and prohibitin 2 in yeast 
Journal:
Indian Journal of Medical Microbiology 
Year:
2020 
Volume:
38 
Page:
213 
Keywords:
Mitochondria, Plasmodium falciparum, prohibitins, supercomplex, yeast two-hybrid analysis 
Abstract:
Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-hybrid analysis, we show that putative Plasmodium PHBs (Pf PHB1 and Pf PHB2) interact with each other, which suggests that they could form supercomplexes of heterodimers in Plasmodium, the functional form required for optimum mitochondrial function. 
Entered by:
Praveen Balabaskaran Nina on 2020-09-03 
 
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