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Applicant:
Central University of Tamil Nadu 
Author:
Indranil Chattopadhyay 
Corresponding Authors:
Indranil Chattopadhyay 
DOI #:
https://doi.org/10.1002/9781119432487.ch3 
Title:
Application of Circulating Cell‐free DNA for Personalized Cancer Therapy 
Journal:
Precision Medicine in Oncology 
Year:
2020 
Volume:
Not Applicable 
Page:
83-97 
Keywords:
circulating tumor DNA, personalized medicine, cancer diagnosis and prognosis 
Abstract:
Cancer is one of the main causes of death all over the world. Advanced therapy becomes unable to increase the survival rate due to the presence of drug‐resistant genetic alterations in tumors. To determine the accurate treatment plan for individual cancer patients, it is essential to monitor genetic and epigenetic changes of tumor progression during therapy. Circulating tumor DNA (ctDNA) is present in serum and plasma freely. ctDNA represents the real‐time screenshot of the primary and metastatic tumor. Collection of ctDNA is a noninvasive method which will allow several samplings at different time points during treatment. Analysis of ctDNA by advanced genomic technologies such as PCR (polymerase chain reaction) and cancer personalized profiling by deep sequencing (CAPP‐Seq) provide drug‐targeted genetic hotspots of the tumor. The clinical importance of ctDNA in cancer diagnosis and prognosis needs to be addressed in personalized cancer managements. Quantity and mutation analysis of ctDNA are used to determine the response of cancer patients to chemotherapy, particularly in breast, lung, and colorectal cancers. 
Entered by:
Indranil Chattopadhyay on 2020-09-03 
 
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