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Applicant:
Central University of Tamil Nadu 
Author:
Vinodhini Krishnakumar, Siva Sundara Kumar Durairajan, Kalichamy Alagarasu , Min Li, Aditya Prasad Dash  
Corresponding Authors:
Siva Sundara Kumar Durairajan, Min Li,  
DOI #:
10.3390/v11030252 
Title:
Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections 
Journal:
Viruses 
Year:
2019 
Volume:
11 
Page:
252 
Keywords:
infectious diseases; human viruses; mouse models; knockout mice; transgenic mice; humanized mice; HIV; influenza; dengue 
Abstract:
Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical investigations. Human viruses, however, seldom infect mice due to differences in the cellular receptors used by the viruses for entry, as well as in the innate immune responses in mice and humans. In other words, a species barrier exists when using mouse models for investigating human viral infections. Developing transgenic (Tg) mice models expressing the human genes coding for viral entry receptors and knock-out (KO) mice models devoid of components involved in the innate immune response have, to some extent, overcome this barrier. Humanized mouse models are a third approach, developed by engrafting functional human cells and tissues into immunodeficient mice. They are becoming indispensable for analyzing human viral diseases since they nearly recapitulate the human disease. These mouse models also serve to test the efficacy of vaccines and antiviral agents. This review provides an update on the Tg, KO, and humanized mouse models that are used in studies investigating the pathogenesis of three important human-specific viruses, namely human immunodeficiency (HIV) virus 1, influenza, and dengue 
Entered by:
Siva Sundara Kumar Durairajan on 2020-09-04 
 
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