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Applicant:
Central University of Tamil Nadu 
Author:
Sarma, D.K., Mohapatra, P.K., Bhattacharyya, D.R., Chellappan, S., Balasubramani, K., Barman, K., Senthil Kumar, N., Dash, A.P., Prakash, A., Balabaskaran Nina, P.  
Corresponding Authors:
Balabaskaran Nina, P.  
DOI #:
https://doi.org/10.3390/microorganisms7120673 
Title:
Malaria in North-East India: Importance and Implications in the Era of Elimination 
Journal:
Microorganisms 
Year:
2019 
Volume:
7(12) 
Page:
673 
Keywords:
North-East India; P. falciparum; P. vivax; An. baimaii; An. minimus; artemisinin combination therapy 
Abstract:
Worldwide and in India, malaria elimination e orts are being ramped up to eradicate the disease by 2030. Malaria elimination e orts in North-East (NE) India will have a great bearing on the overall e orts to eradicate malaria in the rest of India. The first cases of chloroquine and sulfadoxine-pyrimethamine resistance were reported in NE India, and the source of these drug resistant parasites are most likely from South East Asia (SEA). NE India is the only land route through which the parasites from SEA can enter the Indian mainland. India’s malaria drug policy had to be constantly updated due to the emergence of drug resistant parasites in NE India. Malaria is highly endemic in many parts of NE India, and Plasmodium falciparum is responsible for the majority of the cases. Highly ecient primary vectors and emerging secondary vectors complicate malaria elimination e orts in NE India. Many of the high transmission zones in NE India are tribal belts, and are dicult to access. The review details the malaria epidemiology in seven NE Indian states from 2008 to 2018. In addition, the origin and evolution of resistance to major anti-malarials are discussed. Furthermore, the bionomics of primary vectors and emergence of secondary malaria vectors, and possible strategies to prevent and control malaria in NE are outlined 
Entered by:
Balasubramani Karuppusamy on 2020-09-10 
 
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