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  Digital Catalogue for Technology and Products Development


   Technology and Product Development

    Basic Information

Technology developed: Antibacterial Platinum-N-Heterocyclic Carbene Compounds (TP19769313330)
Category: Product(Hardware/Material/Software)
Details of Inventor(s):
Inventor Institution/Organization/Company Department Designation
Dr. Jitendra Kumar Bera IIT Kanpur Chemistry Faculty Member
Dr. Sidharth Chopra CDRI Lucknow Collaborator
Dr. Saravanan Matheshwaran IIT Kanpur Biological Sciences & Bioengineering Faculty Member
Ms. Mandeep Kaur IIT Kanpur Chemistry Student
Mr. Ritesh Thakare CDRI Lucknow Collaborator
Mr. Arindom Bhattacherya IIT Kanpur Chemistry Student
Mr. Prem Anand Murugan IIT Kanpur Biological Sciences & Bioengineering Student
Technical Application Area: Chemicals & Materials Science
If 'Other', please specify:
Please give more details of new technical application area:
Organization(s):
Indian Institute of Technology (IIT) Kanpur
CDRI Lucknow
Affiliated Ministry: MHRD, Govt. of India
Type of technology development: Indigenous
Does the technology help in replacing any import items currently
procured from outside India?
Does the technology have export potential? 1
Category of Technology developed: Futuristic
Stage of Development: Lab-scale
Please describe in detail including the TRL Level:
TRL Level

    Abstract:

Applications: The present invention provides a compound of General Formula or a stereoisomer, a tautomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate or a polymorph thereof, wherein R 1 , R2 , R 3 and R4 are independently selected from hydrogen and straight or branched (C1-C6) alkyl and haloalkyl, or R1, R 2 and R3 , R 4 are independently combined together with one or two atoms of the corresponding pyridyl or imidazole ring to form a 6-8 membered partly unsaturated or saturated carbocycle or heterocycle, wherein the said carbocycle or heterocycle can be unsubstituted or substituted with one or more groups independently selected from the group consisting of alkyl, haloalkyl, hydroxy, halogen, cyano and oxo, R 5 is straight or branched chain C4-C6 terminal alkenyl group, X is a halogen such as fluorine or chlorine, Y represents a bond between platinum metal and the terminal alkenyl group of R5 in chelating mode or can be a halogen such as fluorine or chlorine.
Advantages: 1. A new class of antibiotics with novel modes of actions to fight against drug-resistant pathogens. 2. Provide olefin tethered Platinum-Nheterocyclic carbene compounds useful in the treatment of the effect caused by drug resistant bacteria such as Staphylococcus Aures. 3. Provide a class of compound of General Formula I useful in the treatment of the effect caused by drug resistant bacteria such as Staphylococcus Aures. 4. Provide a process for preparation of olefin tethered Platinum-N-heterocyclic carbene compounds useful in the treatment of the effect caused by drug resistant bacteria such as Staphylococcus Aures. 5. Provide a method of treatment of a patient suffering from the effect caused by drug resistant bacteria such as Staphylococcus Aures by using olefin tethered Platinum-Nheterocyclic carbene compounds.

    Technology Inputs:

Imported Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Indigenous Equipment/Spare Parts:
Equipment/Spare Parts Year ITC-HS Code
NA
Imported Raw Materials:
Raw Materials Year ITC-HS Code
NA
Indigenous Raw Materials:
Raw Materials Year ITC-HS Code
NA
Existing R&D Facilities used:
Facilities Year ITC-HS Code
NA

    R&D Investment:

R&D investment (Rs. in Lakhs):                    
Indian Source (Rs.) Foreign Source (Rs.) Year
0 0 NA

   Patents & Publications:

Patents:
Filed Patents (No.) Granted Patents (No.) Year
1 0 2019-20
Publications:
Submitted (No.) Published (No.) Year
0 0 NA

    Commercialization Potential:

Who are the Potential Licensees?
What commercially available products address
the same problem?
Company Product Problem Addressed
Would you like to develop this invention further with
corporate research support?
Yes
Would you be interested in participating in cluster based
programs for commercialization research or business
planning for your invention?
Yes
      Submitted by: Tarun Gupta Date of Submission: 4-8-2020



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