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Applicant:
Central University of Tamil Nadu 
Author:
Srinivasan Sampath 
Corresponding Authors:
Srinivasan Sampath, Debasis Samanta 
DOI #:
10.1007/s42452-019-0371-1 
Title:
Microcapsules responsive to pH and temperature: synthesis, encapsulation and release study 
Journal:
SN Applied Sciences 
Year:
2019 
Volume:
Page:
448 
Keywords:
Graphene oxide, Thermoresponsive, pH responsive, Polymers, Drug delivery 
Abstract:
In this present article, we report preparation of dual responsive microcapsules by using poly(N-isopropyl acrylamide-comethacrylic acid) [poly(NIPAM-co-MAA)] and acid functionalized graphene oxide (GO). While the methacrylic acid part is responsible for the responsiveness towards the change in pH, N-isopropylacrylamide part is responsible for the responsiveness towards change in temperatures. Functionalized GO forms the core of the microcapsules and its interaction with the polymer controls the movement of the encapsulated materials in response to change in neighboring environment. Surface morphology and interconnectivity of the microcapsules was observed by optical polarized microscopy and the presence of the GO sheets on the wall was observed in High Resolution Transmission Electron Microscopy images. The pH and temperature responsive nature of the microcapsules were studied by loading vitamin B2 or anticancer drug cisplatin. It was found that both pH and temperature influences releasing pattern of the either drug from microcapsule. 
Entered by:
Srinivasan Sampath on 2020-09-01 
 
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