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Applicant:
Central University of Tamil Nadu 
Author:
Mr T Mohan Das  
Corresponding Authors:
I. Sarkar, Hema Malini, A. K. Mishra 
DOI #:
10.1039/C5RA26146E 
Title:
Introduction of an α,β-unsaturated carbonyl conjugated pyrene–lactose hybrid as a fluorescent molecular probe for micro-scale anisotropic media 
Journal:
RSC Advances 
Year:
2016 
Volume:
Page:
27933-27943  
Keywords:
Fluorescent lactose molecule, photo-physical studies, α,β-unsaturated carbonyl conjugated pyrene–lactose hybrid, disaccharide. 
Abstract:
A new fluorescent lactose molecule (pyd-lact) (E)-1-(galactose-β-(1→4)-β-D-glucopyranosyl)-4-(1-pyrene)-but-3-en-2-one, has been synthesized by attaching 1-pyrene-but-3-ene-2-one to lactose. Extended π-conjugation removes the emission forbiddenness of pyrene, which results in the broad spectrum. Detailed photo-physical studies in homogeneous media show the sensitivity of ICT (intra molecular charge transfer) emission towards medium polarity. Unlike pyrene, pyd-lact is more soluble in water at a probe concentration of 10 μM, because of the attached disaccharide. Thus, the usage of pyd-lact as an aqueous probe is found to be advantageous over pyrene. Using the polarity sensitivity of fluorescence parameters (intensity, shift of emission maximum, anisotropy, lifetime), the micro-heterogeneity of anisotropic media such as β-CD, bile salts, and Pluronic P123 have been monitored. In contrast to pyrene-3-carboxaldehyde, which is often used as a hydrophobic fluorescent molecular probe, pyd-lact reports from the interfacial regions of micro-heterogeneous media. 
Entered by:
Mohan Das Thangamuthu on 2020-09-02 
 
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