Indian Science Technology and Engineering facilities Map
Supplier Map
Service Map

Publications

Publication Details

Applicant:
Central University of Tamil Nadu 
Author:
Nagini, Siddavaram; Kiran Kishore Tanagala, Kranthi; Chattopadhyay, Indranil 
Corresponding Authors:
Nagini, Siddavaram 
DOI #:
Not applicable 
Title:
NF-Κ B Inhibitors in Head and Neck Cancer 
Journal:
Letters in Drug Design & Discovery, 
Year:
2017 
Volume:
14 
Page:
619-633 
Keywords:
Bortezomib; NF-ΚB; NF-ΚB inhibitors; cancer hallmarks; chemosensitivity; head and neck squamous cell carcinoma; radiosensitivity 
Abstract:
Overexpression and aberrant activation of NF-ΚB has been extensively documented during the development and progression of head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer worldwide. Accumulating evidence indicates that NF-ΚB plays a central role in HNSCC development via regulation of a multitude of genes involved in cell proliferation, cell survival, apoptosis evasion, inflammation, immune functions, stress response, invasion, metastasis, angiogenesis and resistance to anticancer therapies. Different classes of drugs, chemicals, dietary agents, medicinal plants and phytochemicals have been demonstrated to inhibit NF-ΚB signalling at various levels including upstream of IKK, directly at the IKK complex, phosphorylation of IΚB, ubiquitination or proteasomal degradation of IΚB; nuclear translocation of NF-ΚB and binding of NF- ΚB to DNA. NF-ΚB expression has been suggested as a novel marker of chemo- and radiotherapy resistance. Downregulation or knockdown of NF-ΚB activators, combination chemotherapy, as well as natural products that inhibit NF-ΚB signalling confer chemoradiosensitivity. In particular, inhibition of proteasomal degradation of IΚB has evolved as an important tool for pharmacological intervention. Further investigation to identify NF-ΚB inhibitors with greater specificity, efficacy and safety as well as strategies to intensify chemo-radiosensitivity will aid in the prevention and treatment of HNSCC. 
Entered by:
Indranil Chattopadhyay on 2020-09-03 
 
I-Mitra(आई-मित्र) Welcomes You..
THE VISION
THE MISSION
ABOUT I-STEM
It has always been the basic tenet of the Government of India, in generously funding R&D efforts at academic institutions over the years, that facilities established through such support be made available to those needing them and qualified to make use of them for their own research work
read more >>

However, this was never easy or straightforward for, among other reasons, there was no ready source of information of what facility was available and where. Thanks to the Web, it is much easier today to have a national and regional “inventory of resources”, so as to match users with the resources they need, and to do all this in an efficient and transparent manner.

This can lead to a leap in R&D productivity and greatly enhance the effectiveness of public investment. This is the motivation behind I-STEM.
read less <<
Visitor Hit Counter
Hosted at Indian Institute of Science
Copyright © 2020 I-STEM. All rights reserved.
Audited by: STQC Bengaluru.